Histology Certification Pathological Changes 2

Question 1

Which term describes irreversible cell injury characterized by cell swelling, membrane rupture, and inflammation?

Accepted Answer

Necrosis

Answer

Necrosis is an uncontrolled, irreversible form of cell death associated with membrane disruption and inflammatory response.

Question 2

In coagulative necrosis, the tissue architecture is preserved because of which of the following?

Accepted Answer

Protein denaturation prevents autolysis

Answer

In coagulative necrosis, heat or ischemia denatures structural proteins, including enzymes, preventing autolytic digestion and preserving tissue architecture.

Question 3

Liquefactive necrosis is characteristically seen in infarcts of which organ?

Accepted Answer

Brain

Answer

The brain undergoes liquefactive necrosis because its high lipid content and abundance of hydrolytic enzymes lead to rapid digestion of necrotic tissue.

Question 4

Caseous necrosis, which appears as soft, cheese-like material on gross examination, is most associated with infection by which organism?

Accepted Answer

Mycobacterium tuberculosis

Answer

Caseous necrosis is a hallmark of granulomatous inflammation caused by Mycobacterium tuberculosis.

Question 5

Fat necrosis secondary to acute pancreatitis results from the action of which enzymes released by damaged pancreatic cells?

Accepted Answer

Lipases and phospholipases

Answer

Pancreatic lipases and phospholipases digest adipose tissue triglycerides, releasing fatty acids that combine with calcium to form saponification (chalky deposits).

Histology Certification Practice Test

Histology Certification Practice Test

Histology Certification Pathological Changes 2