GPhC Clinical Therapeutics & BNF Guidelines

Question 1

According to NICE guidelines, what is the first-line treatment for newly diagnosed type 2 diabetes alongside lifestyle advice?

Accepted Answer

Metformin

Answer

Gliclazide

Answer

Sitagliptin

Answer

Insulin glargine

Question 2

The BNF recommends stopping which drug at least 48 hours before iodine-containing contrast media in patients with eGFR <60?

Accepted Answer

Metformin

Answer

Atorvastatin

Answer

Amlodipine

Answer

Omeprazole

Question 3

Which antihypertensive is recommended as first-line for a 55-year-old Caucasian patient without diabetes?

Accepted Answer

Amlodipine (calcium channel blocker)

Answer

Lisinopril (ACE inhibitor)

Answer

Atenolol (beta-blocker)

Answer

Spironolactone

Question 4

Which antibiotic is first-line for uncomplicated lower urinary tract infection in women according to NICE?

Accepted Answer

Nitrofurantoin

Answer

Co-amoxiclav

Answer

Ciprofloxacin

Answer

Trimethoprim (if local resistance low)

Question 5

A patient taking warfarin is prescribed clarithromycin. What interaction should you counsel about?

Accepted Answer

Increased INR and bleeding risk

Answer

Reduced warfarin absorption

Answer

Decreased INR

Answer

No clinically significant interaction

Question 6

Which NSAID is associated with the lowest cardiovascular risk according to current evidence?

Accepted Answer

Naproxen

Answer

Diclofenac

Answer

Ibuprofen high-dose

Answer

Celecoxib