EDAIC Coagulation and Transfusion Medicine 3

Question 1

Which product should be given to a patient with hemophilia A who is bleeding acutely?

Accepted Answer

Factor VIII concentrate

Answer

Factor VIII concentrate is the preferred treatment for acute bleeding in hemophilia A.

Question 2

What is the target fibrinogen level in massive hemorrhage according to current guidelines?

Accepted Answer

Above 1.5–2.0 g/L

Answer

Guidelines recommend maintaining fibrinogen above 1.5–2.0 g/L during active massive hemorrhage.

Question 3

Protamine sulfate is used to reverse heparin. What is the primary adverse effect of rapid protamine administration?

Accepted Answer

Hypotension and bradycardia

Answer

Rapid protamine infusion causes histamine release leading to hypotension and bradycardia.

Question 4

Which platelet count threshold generally triggers prophylactic platelet transfusion in a non-bleeding, non-surgical ICU patient?

Accepted Answer

<20–10 × 10⁹/L

Answer

Prophylactic transfusion is typically indicated when platelets fall below 10–20 × 10⁹/L in stable patients.

Question 5

Tranexamic acid works by which mechanism?

Accepted Answer

Blocking plasminogen activation and inhibiting fibrinolysis

Answer

Tranexamic acid competitively inhibits plasminogen binding, preventing fibrinolysis.

EDAIC - European Diploma in Anesthesiology and Intensive Care Practice Test