A 55-year-old patient with sepsis develops moderate-to-severe ARDS, with a PaO2/FiO2 ratio of 110 mmHg.
The patient is ventilated according to a lung-protective strategy (6 mL/kg predicted body weight, plateau pressure < 30 cmH2O).
Which of the following adjunctive therapies has demonstrated the most significant mortality benefit in this patient population?