EDAIC Basic Sciences 3

Question 1

In the context of EDAIC pharmacology, the volume of distribution (Vd) of a drug is best described as:

Accepted Answer

A theoretical volume relating dose to plasma concentration

Answer

Vd = Dose / Cp, a theoretical construct reflecting how extensively a drug distributes into tissues relative to plasma.

Question 2

Which enzyme is responsible for the metabolism of remifentanil, giving it an ultra-short context-sensitive half-time?

Accepted Answer

Non-specific blood and tissue esterases

Answer

Remifentanil contains an ester linkage hydrolyzed by ubiquitous non-specific esterases in blood and tissues, making its elimination independent of organ function.

Question 3

The Frank-Starling mechanism describes the relationship between:

Accepted Answer

Ventricular end-diastolic volume and stroke volume

Answer

The Frank-Starling law states that stroke volume increases as end-diastolic volume (preload) increases, up to a physiological limit.

Question 4

Which region of the nephron is the PRIMARY site of sodium reabsorption under aldosterone's influence?

Accepted Answer

Distal tubule and collecting duct

Answer

Aldosterone acts on principal cells of the distal tubule and collecting duct to upregulate Na+/K+-ATPase and ENaC channels, increasing sodium reabsorption.

Question 5

Minimum alveolar concentration (MAC) of a volatile anesthetic is defined as the concentration that prevents movement in response to surgical incision in what percentage of patients?

Accepted Answer

50%

Answer

MAC is the alveolar concentration at 1 atm that prevents purposeful movement in 50% of patients in response to a standard noxious stimulus.

EDAIC - European Diploma in Anesthesiology and Intensive Care Practice Test

EDAIC - European Diploma in Anesthesiology and Intensive Care Practice Test

EDAIC Basic Sciences 3