DDS Oral Pathology and Oral Medicine 3

Question 1

Pemphigus vulgaris involves oral mucosa due to autoantibodies directed against:

Accepted Answer

Desmoglein-3 (desmosomal adhesion protein)

Answer

Pemphigus vulgaris results from IgG autoantibodies against desmoglein-3 (and sometimes desmoglein-1), disrupting intercellular adhesion and causing intraepithelial blistering.

Question 2

Which feature most distinguishes odontogenic keratocyst from other jaw cysts histologically?

Accepted Answer

Thin corrugated parakeratinized epithelium with a basal cell layer showing palisading

Answer

OKC has a distinctive thin, uniform parakeratinized stratified squamous epithelium with a prominent palisaded cuboidal-to-columnar basal cell layer and corrugated surface.

Question 3

Fordyce spots in the oral cavity represent:

Accepted Answer

Ectopic sebaceous glands in the oral mucosa

Answer

Fordyce spots are ectopic sebaceous glands that appear as small yellowish spots on the buccal mucosa and lips, a normal variant requiring no treatment.

Question 4

Necrotizing ulcerative gingivitis (NUG) is caused by synergistic infection involving which organisms?

Accepted Answer

Spirochetes (Treponema) and fusiform bacteria (Fusobacterium nucleatum)

Answer

NUG is a polymicrobial anaerobic infection with spirochetes and fusiform bacteria (Fusobacterium-spirochete complex) as the principal causative agents.

Question 5

Geographic tongue (benign migratory glossitis) is characterized by:

Accepted Answer

Migratory areas of erythema surrounded by a white keratotic border that change over days

Answer

Geographic tongue shows irregular areas of desquamation of filiform papillae (red zones) with a white serpiginous border that shifts location over days to weeks.

DDS - Doctor of Dental Surgery Practice Test

DDS - Doctor of Dental Surgery Practice Test

DDS Oral Pathology and Oral Medicine 3