CTA CTA Biostatistics & Study Design 1

Question 1

Which type of clinical trial design randomly assigns participants to treatment or control groups to minimize bias?

Accepted Answer

Randomized controlled trial (RCT)

Answer

A randomized controlled trial (RCT) uses random assignment to treatment or control groups, which is the gold standard for minimizing selection bias in clinical research.

Question 2

In a double-blind clinical trial, who is unaware of the treatment assignment?

Accepted Answer

Both the participant and the investigator

Answer

In a double-blind study, both the participant and the investigator are unaware of treatment assignments to prevent performance and detection bias.

Question 3

What is a Phase I clinical trial primarily designed to evaluate?

Accepted Answer

Safety and dosing in a small group of healthy volunteers

Answer

Phase I trials are the first human studies focused on assessing safety, tolerability, and pharmacokinetics in a small group, typically healthy volunteers.

Question 4

What does the term 'placebo-controlled' mean in a clinical trial?

Accepted Answer

A control group receives an inactive substance identical in appearance to the treatment

Answer

In a placebo-controlled trial, the control group receives an inert substance that looks identical to the active treatment, allowing true comparison of treatment effects.

Question 5

Which study design follows a group of participants over time to assess outcomes?

Accepted Answer

Cohort study

Answer

A cohort study follows a defined group of people (a cohort) over time to observe outcomes, making it effective for studying incidence and causality.

(CTA) Clinical Trial Associate Certification Practice Test

(CTA) Clinical Trial Associate Certification Practice Test

CTA CTA Biostatistics & Study Design 1