CRNI Infusion-Related Pharmacology 2

Question 1

What is the primary concern when administering vancomycin IV too rapidly?

Accepted Answer

Red man syndrome

Answer

Rapid vancomycin infusion causes histamine release resulting in red man syndrome, characterized by flushing, erythema, and hypotension of the upper body.

Question 2

Which drug-drug interaction is MOST dangerous when co-administering IV heparin and nitroglycerin?

Accepted Answer

Decreased heparin efficacy requiring higher doses

Answer

IV nitroglycerin can decrease heparin's anticoagulant effect, requiring increased heparin doses that may cause bleeding complications when nitroglycerin is discontinued.

Question 3

What is the correct method for calculating an IV drug infusion rate when given mg/kg/min dosing?

Accepted Answer

Multiply the dose by patient weight, divide by concentration, multiply by 60

Answer

For weight-based infusion calculations: (dose in mg/kg/min multiplied by patient weight in kg divided by drug concentration in mg/mL) multiplied by 60 equals infusion rate in mL/hr.

Question 4

Which IV medication requires protection from light during infusion?

Accepted Answer

Nitroprusside

Answer

Nitroprusside is highly photosensitive and must be protected from light during preparation and infusion to prevent degradation to cyanide.

Question 5

What is the pharmacological rationale for using a 0.22-micron in-line filter during IV infusion?

Accepted Answer

To remove particulate matter, microorganisms, and endotoxins

Answer

A 0.22-micron filter removes particulate matter, bacteria, fungi, and endotoxins from the infusate, providing an additional safety barrier against contamination.

CRNI Exam Practice Test

CRNI Exam Practice Test

CRNI Infusion-Related Pharmacology 2