CRNI Infusion-Related Pharmacology 2

Question 1

What is the primary concern when administering vancomycin IV too rapidly?

Accepted Answer

Red man syndrome

Answer

Nephrotoxicity

Answer

Ototoxicity

Answer

Hepatotoxicity

Question 2

Which drug-drug interaction is MOST dangerous when co-administering IV heparin and nitroglycerin?

Accepted Answer

Decreased heparin efficacy requiring higher doses

Answer

Increased bleeding risk from potentiated anticoagulation

Answer

Nitroglycerin precipitation in the IV line

Answer

Cardiovascular collapse from synergistic vasodilation

Question 3

What is the correct method for calculating an IV drug infusion rate when given mg/kg/min dosing?

Accepted Answer

Multiply the dose by patient weight, divide by concentration, multiply by 60

Answer

Simply multiply the dose by the drip factor

Answer

Use the patient's ideal body weight and round to the nearest 10 mL/hr

Answer

Divide the total bag volume by the desired infusion time

Question 4

Which IV medication requires protection from light during infusion?

Accepted Answer

Nitroprusside

Answer

Ceftriaxone

Answer

Metronidazole

Answer

Piperacillin-tazobactam

Question 5

What is the pharmacological rationale for using a 0.22-micron in-line filter during IV infusion?

Accepted Answer

To remove particulate matter, microorganisms, and endotoxins

Answer

To filter out air bubbles only

Answer

To slow the infusion rate

Answer

To prevent drug precipitation visible to the eye only

Question 6

A patient receiving IV phenytoin develops burning at the peripheral IV site with a pH of the infusate measured at 12. What action should the nurse take?

Accepted Answer

Stop the infusion, assess for extravasation, and consider central line placement for continuation

Answer

Apply a warm compress and continue the infusion

Answer

Dilute the phenytoin further and resume peripherally

Answer

Increase the infusion rate to minimize contact time