Late Effects of Childhood Cancer Treatment Flashcards
6 cards from real CPHON practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 Late Effects of Childhood Cancer Treatment flashcards as text
Which late effect associated with high-dose cyclophosphamide should the CPHON nurse monitor for in long-term survivors?
Answer: Hemorrhagic cystitis and bladder fibrosis
Cyclophosphamide is metabolized to acrolein, which is directly toxic to bladder urothelium, causing acute hemorrhagic cystitis and long-term bladder fibrosis and reduced bladder capacity.
A childhood ALL survivor's parents ask about dental late effects from their child's chemotherapy and radiation. Which finding is most expected?
Answer: Root foreshortening and enamel hypoplasia
Chemotherapy and cranial/jaw radiation during dental development cause root foreshortening, enamel hypoplasia, and microdontia as developing tooth buds are damaged.
Which ophthalmologic late effect should the nurse assess for in survivors who received cranial radiation involving the eye fields or high-dose corticosteroids?
Answer: Cataracts
Both cranial radiation (especially when it includes the lens) and prolonged corticosteroid use are associated with posterior subcapsular cataracts as a late ophthalmologic effect.
A CPHON nurse is reviewing the survivorship care plan for a patient who received platinum-based chemotherapy. Which kidney-related late effect requires ongoing monitoring?
Answer: Cisplatin-induced renal tubular dysfunction and Fanconi syndrome
Cisplatin causes direct tubular toxicity, most significantly affecting the proximal tubule. This can result in Fanconi syndrome—renal tubular acidosis, phosphate wasting, hypomagnesemia, and aminoaciduria.
Which psychosocial late effect is most prevalent among childhood cancer survivors?
Answer: Post-traumatic stress symptoms and anxiety
Survivors of childhood cancer have significantly elevated rates of post-traumatic stress symptoms (PTSS), anxiety, and depression compared to healthy peers and siblings, related to the trauma of diagnosis and treatment.
According to the Children's Oncology Group (COG) Long-Term Follow-Up Guidelines, how frequently should echocardiography be performed in a survivor who received anthracyclines with a cumulative dose of 250 mg/m²?
Answer: Every 2 years
COG LTFU guidelines recommend echocardiography every 2 years for survivors who received anthracycline doses of 250–299 mg/m², with more frequent monitoring for higher doses or additional cardiac risk factors.