CPC CPC Organic Chemistry & Synthesis 3

Question 1

Which synthesis method involves the condensation of an aldehyde with a compound bearing an active methylene group under basic or acidic conditions?

Accepted Answer

Aldol condensation

Answer

The aldol condensation joins an enolizable carbonyl compound to an aldehyde or ketone, followed by dehydration to form an α,β-unsaturated carbonyl product.

Question 2

A chiral molecule that is NOT superimposable on its mirror image is called a(n):

Accepted Answer

Enantiomer pair member

Answer

A chiral molecule and its mirror image are non-superimposable and are called enantiomers, exhibiting identical physical properties except for rotation of plane-polarized light.

Question 3

What is the role of the palladium catalyst in a Suzuki coupling reaction?

Accepted Answer

Undergoes oxidative addition, transmetalation, and reductive elimination cycle

Answer

In Suzuki coupling, Pd(0) undergoes oxidative addition into the aryl halide, then transmetalation with the boronic acid, followed by reductive elimination to form the biaryl product.

Question 4

In retrosynthetic analysis, the disconnection approach is used to:

Accepted Answer

Work backward from product to identify viable synthetic precursors

Answer

Retrosynthetic analysis disconnects the target molecule into simpler precursors by identifying logical bond disconnections, working backward to commercially available starting materials.

Question 5

Which reaction would you use to introduce a carboxyl group onto a terminal alkyne?

Accepted Answer

Carboxylation with CO2 after forming an acetylide anion

Answer

Deprotonation of a terminal alkyne with a strong base forms an acetylide anion, which reacts with CO2 to give a carboxylate (propiolic acid derivative) after acidification.

(CPC) Certified Professional Chemist Practice Test

(CPC) Certified Professional Chemist Practice Test

CPC CPC Organic Chemistry & Synthesis 3