CPC CPC Organic Chemistry & Synthesis 3

Question 1

Which synthesis method involves the condensation of an aldehyde with a compound bearing an active methylene group under basic or acidic conditions?

Accepted Answer

Aldol condensation

Answer

Claisen condensation

Answer

Mannich reaction

Answer

Michael addition

Question 2

A chiral molecule that is NOT superimposable on its mirror image is called a(n):

Accepted Answer

Enantiomer pair member

Answer

Meso compound

Answer

Constitutional isomer

Answer

Conformational isomer

Question 3

What is the role of the palladium catalyst in a Suzuki coupling reaction?

Accepted Answer

Undergoes oxidative addition, transmetalation, and reductive elimination cycle

Answer

Acts as a Lewis acid to activate the boron reagent

Answer

Provides a radical initiation step

Answer

Acts as a proton donor

Question 4

In retrosynthetic analysis, the disconnection approach is used to:

Accepted Answer

Work backward from product to identify viable synthetic precursors

Answer

Predict reaction rates

Answer

Determine the mechanism of a reaction

Answer

Calculate yield of a multistep synthesis

Question 5

Which reaction would you use to introduce a carboxyl group onto a terminal alkyne?

Accepted Answer

Carboxylation with CO2 after forming an acetylide anion

Answer

Wacker oxidation

Answer

Ozonolysis

Answer

Hydroboration-oxidation

Question 6

Which of the following describes the principle of microscopic reversibility in organic mechanisms?

Accepted Answer

The reverse reaction proceeds via the same transition states and intermediates as the forward reaction, in reverse

Answer

The forward and reverse reactions must have the same rate constant

Answer

Catalysts change the equilibrium position

Answer

Only exothermic reactions are reversible