COKO Pharmacology Fundamentals 3

Question 1

The volume of distribution (Vd) of a drug is very large. What does this indicate about the drug's distribution?

Accepted Answer

The drug is extensively distributed into tissues

Answer

A large Vd indicates the drug distributes widely into peripheral tissues rather than remaining in the plasma compartment.

Question 2

A client on ACE inhibitors for hypertension complains of a persistent dry cough. This side effect is best explained by accumulation of:

Accepted Answer

Bradykinin

Answer

ACE inhibitors block the enzyme that also degrades bradykinin; bradykinin accumulation stimulates cough receptors in the airways.

Question 3

Which type of drug-receptor interaction is reversible and follows the law of mass action?

Accepted Answer

Competitive antagonism

Answer

Competitive antagonists bind reversibly at the receptor's active site and can be displaced by increasing agonist concentration.

Question 4

A kinesiologist is working with a client who takes a statin for dyslipidemia. Which exercise-related adverse effect should be monitored?

Accepted Answer

Statin-associated myopathy or myalgia

Answer

Statins can cause muscle pain, weakness, or in rare cases rhabdomyolysis, which is exacerbated by intense exercise.

Question 5

A drug with a narrow therapeutic index requires careful dosing because:

Accepted Answer

The toxic dose is close to the effective dose

Answer

A narrow therapeutic index means small dosing errors can result in sub-therapeutic or toxic drug concentrations.

(COKO) College of Kinesiologists of Ontario Practice Test