CCTN Post-Transplant Immunosuppressive Medications 2

Question 1

A renal transplant patient on mycophenolate mofetil reports severe diarrhea and nausea. What is the most appropriate nursing intervention?

Accepted Answer

Document and notify the provider — dose reduction or switch to EC-MPS may be needed

Answer

Reassure the patient that GI side effects are expected and will resolve

Answer

Discontinue MMF immediately without provider notification

Answer

Administer an antiemetic and continue the current dose

Question 2

Cyclosporine A is associated with which distinctive cosmetic side effect not seen with tacrolimus?

Accepted Answer

Gingival hyperplasia

Answer

Alopecia

Answer

Moon face

Answer

Acne

Question 3

Which drug interaction is most clinically significant for transplant patients taking tacrolimus?

Accepted Answer

CYP3A4 inhibitors such as fluconazole significantly increase tacrolimus levels

Answer

Concurrent use of aspirin

Answer

Concurrent use of beta blockers

Answer

Vitamin C supplementation

Question 4

Prednisone is used in transplant regimens primarily for which mechanism?

Accepted Answer

Broad anti-inflammatory and immunosuppressive effects via glucocorticoid receptor activation

Answer

Selective T-cell depletion

Answer

Inhibition of IL-2 production specifically

Answer

Blocking B-cell antibody production

Question 5

A liver transplant patient is started on sirolimus. Which side effect should the nurse educate the patient about?

Accepted Answer

Impaired wound healing and hyperlipidemia

Answer

Peripheral neuropathy

Answer

Gingival hyperplasia

Answer

Uveitis

Question 6

Basiliximab is an induction agent that acts by blocking which interleukin receptor?

Accepted Answer

IL-2 receptor (CD25)

Answer

IL-4 receptor

Answer

IL-6 receptor

Answer

IL-17 receptor