CCTC CCTC - Certified Clinical Transplant Coordinator Infection Prevention and Management Questions and Answers 2

Question 1

When BK viremia is detected on surveillance in a kidney transplant recipient, the standard first intervention is:

Accepted Answer

Reducing immunosuppression, typically by decreasing mycophenolate dose

Answer

Adding antiviral therapy with ganciclovir

Answer

Initiating empiric antibiotics

Answer

Performing an immediate kidney biopsy without any other change

Question 2

Which live vaccine is CONTRAINDICATED in immunocompromised solid organ transplant recipients?

Accepted Answer

MMR (measles, mumps, rubella)

Answer

Inactivated influenza (IIV)

Answer

Recombinant zoster vaccine (RZV/Shingrix)

Answer

Pneumococcal polysaccharide vaccine (PPSV23)

Question 3

Annual inactivated influenza vaccination is recommended for transplant recipients primarily because:

Accepted Answer

Influenza infection can trigger acute rejection and cause severe disease in immunocompromised hosts

Answer

It is required by UNOS policy

Answer

It prevents CMV reactivation

Answer

It is mandated by Medicare conditions of participation

Question 4

A liver transplant recipient who received a TB-positive donor organ (via IGRA) requires post-transplant treatment. The preferred regimen for latent TB infection (LTBI) treatment in this setting is:

Accepted Answer

Isoniazid (INH) for 9 months with vitamin B6 supplementation

Answer

Immediate four-drug active TB therapy for 9 months

Answer

No treatment needed if the recipient is IGRA-negative

Answer

Rifampin for 4 months, preferred over isoniazid in transplant recipients

Question 5

The MOST important preventive measure a transplant coordinator can reinforce to reduce surgical site infection (SSI) after transplant surgery is:

Accepted Answer

Strict hand hygiene and proper wound care as instructed by the surgical team

Answer

Avoiding all physical activity for 12 months

Answer

Taking prophylactic broad-spectrum antibiotics indefinitely

Answer

Avoiding all contact with other people for 6 months

Question 6

Epstein-Barr virus (EBV) reactivation post-transplant is most concerning because it is associated with the development of:

Accepted Answer

Post-transplant lymphoproliferative disorder (PTLD)

Answer

BK nephropathy

Answer

Hepatitis C recurrence

Answer

Cytomegalovirus retinitis