CCRN Hematology and Immunology 3

Question 1

Which blood product is the treatment of choice to rapidly reverse warfarin in a patient with life-threatening bleeding?

Accepted Answer

Prothrombin complex concentrate (PCC)

Answer

PCC provides concentrated vitamin K-dependent factors and reverses warfarin faster than fresh frozen plasma for life-threatening bleeding.

Question 2

Cryoprecipitate is most specifically indicated to replace which component?

Accepted Answer

Fibrinogen

Answer

Cryoprecipitate is rich in fibrinogen, factor VIII, von Willebrand factor, and factor XIII, and is used primarily for low fibrinogen.

Question 3

A patient develops dyspnea, hypoxemia, and bilateral infiltrates within 6 hours of transfusion. Which reaction is most likely?

Accepted Answer

Transfusion-related acute lung injury (TRALI)

Answer

TRALI presents with acute non-cardiogenic pulmonary edema within 6 hours of transfusion and is a leading cause of transfusion-related death.

Question 4

Which assessment finding distinguishes TACO (circulatory overload) from TRALI?

Accepted Answer

Hypertension and elevated BNP with jugular venous distention

Answer

TACO is volume overload, so it presents with hypertension, elevated BNP, and JVD, unlike TRALI which has normal filling pressures.

Question 5

A patient with hemophilia A is bleeding. Which factor must be replaced?

Accepted Answer

Factor VIII

Answer

Hemophilia A is a deficiency of factor VIII, which must be replaced to control bleeding.

CCRN Review Practice Test