What is the primary pharmacological difference between methadone and buprenorphine in treating opioid use disorder?
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A
Methadone is a partial agonist; buprenorphine is a full agonist
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B
Methadone is a full agonist; buprenorphine is a partial agonist with a ceiling effect
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C
Both are full agonists but differ in half-life only
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D
Buprenorphine requires daily clinic visits; methadone does not