Methadone, when used as medication-assisted treatment for opioid use disorder, differs from buprenorphine in a clinically significant way. Which of the following statements accurately describes a key distinction?
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A
Methadone is a partial opioid agonist, while buprenorphine is a full opioid agonist
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B
Methadone for OUD must be dispensed through a federally certified Opioid Treatment Program (OTP), while buprenorphine can be prescribed in office-based settings
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C
Methadone carries no risk of overdose, making it safer than buprenorphine for outpatient use
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D
Methadone requires naloxone co-formulation to prevent misuse