A patient stabilized on buprenorphine/naloxone needs emergency surgery. The anesthesiologist asks about managing pain perioperatively. The MOST accurate guidance is:
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A
Buprenorphine must be stopped 72 hours before surgery to allow full opioid analgesia
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B
Buprenorphine's high receptor affinity may reduce effectiveness of full opioid agonists; higher opioid doses or regional anesthesia may be needed
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C
Naloxone in the formulation will reverse all analgesia, so it must be discontinued first
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D
Buprenorphine provides sufficient post-operative analgesia and no supplemental opioids are ever needed