BCACP Clinical Literature Interpretation 2

Question 1

A randomized controlled trial reports a relative risk reduction (RRR) of 30% for a primary endpoint. The control event rate is 5%. What is the absolute risk reduction (ARR)?

Accepted Answer

1.5%

Answer

ARR = RRR × control event rate = 0.30 × 5% = 1.5%.

Question 2

Which statistical test is most appropriate for comparing means across three or more independent groups in a clinical trial?

Accepted Answer

One-way ANOVA

Answer

One-way ANOVA compares means among three or more independent groups simultaneously.

Question 3

A study uses an intention-to-treat (ITT) analysis. Which statement best describes this approach?

Accepted Answer

All randomized patients are analyzed in their originally assigned groups regardless of protocol adherence

Answer

ITT preserves randomization by analyzing all participants in their originally assigned groups, minimizing bias.

Question 4

A meta-analysis reports an I² statistic of 75%. How should this be interpreted?

Accepted Answer

High heterogeneity exists among the included studies

Answer

An I² of ≥75% indicates substantial heterogeneity, questioning the validity of pooling results.

Question 5

In a pharmacokinetic study, which parameter best describes the rate of drug elimination?

Accepted Answer

Elimination half-life

Answer

Elimination half-life reflects the time required to reduce plasma drug concentration by 50%, representing elimination rate.

BCACP - Board Certified Ambulatory Care Pharmacist Exam Practice Test

BCACP - Board Certified Ambulatory Care Pharmacist Exam Practice Test

BCACP Clinical Literature Interpretation 2