ABOG ABOG Oncology & Gynecologic Cancers 2

Question 1

Which vulvar cancer subtype is most common and most strongly associated with HPV infection?

Accepted Answer

Basaloid/warty squamous cell carcinoma

Answer

Basaloid and warty squamous cell carcinomas of the vulva are HPV-associated subtypes most commonly seen in younger women, whereas keratinizing SCC occurs in older women with lichen sclerosus.

Question 2

The International Federation of Gynecology and Obstetrics (FIGO) Stage IIIC1 ovarian cancer indicates tumor spread to which location?

Accepted Answer

Retroperitoneal lymph nodes only

Answer

FIGO Stage IIIC1 ovarian cancer is defined by retroperitoneal lymph node metastasis only, without other peritoneal implants beyond the pelvis.

Question 3

Which chemotherapy regimen is the standard of care for primary treatment of advanced-stage epithelial ovarian cancer?

Accepted Answer

Carboplatin + paclitaxel

Answer

Carboplatin plus paclitaxel given every 3 weeks (or weekly) remains the standard first-line chemotherapy regimen for advanced epithelial ovarian cancer.

Question 4

A postmenopausal woman presents with vaginal bleeding. Endometrial sampling shows complex atypical hyperplasia. What is the recommended management?

Accepted Answer

Total hysterectomy with bilateral salpingo-oophorectomy

Answer

Complex atypical endometrial hyperplasia in a postmenopausal woman carries a ~25–40% risk of concurrent or subsequent endometrial carcinoma, making hysterectomy with BSO the definitive treatment.

Question 5

Which gestational trophoblastic neoplasm has the worst prognosis and requires combination chemotherapy?

Accepted Answer

Choriocarcinoma with high-risk features

Answer

High-risk choriocarcinoma (WHO score ≥7) requires multi-agent chemotherapy such as EMA-CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) due to resistance to single-agent therapy.

(ABOG) American Board of Obstetrics & Gynecology Practice Test

(ABOG) American Board of Obstetrics & Gynecology Practice Test

ABOG ABOG Oncology & Gynecologic Cancers 2