ABA Pharmacology Fundamentals 3

Question 1

Neostigmine reverses neuromuscular blockade primarily by:

Accepted Answer

Inhibiting acetylcholinesterase, increasing ACh at the neuromuscular junction

Answer

Neostigmine inhibits acetylcholinesterase, preventing ACh breakdown and increasing its concentration to compete with nondepolarizing NMBAs.

Question 2

Dexmedetomidine produces its sedative and analgesic effects primarily through:

Accepted Answer

Agonism at central alpha-2 adrenergic receptors in the locus coeruleus

Answer

Dexmedetomidine acts on alpha-2 receptors in the locus coeruleus to reduce noradrenergic output, producing sedation and analgesia without respiratory depression.

Question 3

Which statement about ketamine is correct regarding its cardiovascular effects?

Accepted Answer

It indirectly stimulates the cardiovascular system by increasing sympathetic tone

Answer

Ketamine stimulates the sympathetic nervous system, increasing catecholamine release, which raises heart rate, blood pressure, and cardiac output.

Question 4

A patient develops prolonged neuromuscular blockade after succinylcholine. The most likely cause is:

Accepted Answer

Pseudocholinesterase deficiency

Answer

Pseudocholinesterase (plasma cholinesterase) is responsible for metabolizing succinylcholine; deficiency or atypical enzyme variants dramatically prolong its duration.

Question 5

Propofol's antiemetic properties are thought to be due to:

Accepted Answer

Inhibition of dopamine release in the chemoreceptor trigger zone

Answer

Propofol inhibits dopaminergic transmission in the chemoreceptor trigger zone, contributing to its antiemetic properties.

(ABA) American Board of Anesthesiology Practice Test

(ABA) American Board of Anesthesiology Practice Test

ABA Pharmacology Fundamentals 3