ABA Pharmacology Fundamentals 2

Question 1

Which opioid is most appropriate for a patient with renal failure due to its lack of active metabolite accumulation?

Accepted Answer

Fentanyl

Answer

Fentanyl is preferred in renal failure because it lacks clinically significant active metabolites that accumulate with impaired clearance.

Question 2

The mechanism by which volatile anesthetics produce immobility is primarily through action at:

Accepted Answer

Glycine and GABA-A receptors in the spinal cord

Answer

Immobility produced by volatile anesthetics is primarily mediated by enhanced inhibitory signaling at glycine and GABA-A receptors in the spinal cord dorsal horn.

Question 3

A patient on chronic phenytoin therapy requires higher doses of rocuronium. This is best explained by:

Accepted Answer

Induction of hepatic CYP enzymes accelerating rocuronium metabolism

Answer

Phenytoin induces hepatic CYP enzymes, accelerating the metabolism of rocuronium and reducing its duration and potency.

Question 4

Which pharmacokinetic parameter best predicts the duration of action of a single bolus dose of a highly lipophilic drug like thiopental?

Accepted Answer

Volume of distribution

Answer

With highly lipophilic drugs like thiopental, redistribution into peripheral tissues (reflected by volume of distribution) terminates the effect of a single bolus, not elimination.

Question 5

Succinylcholine causes hyperkalemia by which mechanism?

Accepted Answer

Causing prolonged depolarization and potassium efflux through ACh receptors

Answer

Succinylcholine depolarizes the motor end plate, and potassium leaks out through persistently open ACh receptor channels, raising serum potassium.

(ABA) American Board of Anesthesiology Practice Test

(ABA) American Board of Anesthesiology Practice Test

ABA Pharmacology Fundamentals 2