AANP Pharmacology 3

Question 1

Which blood pressure medication class is absolutely contraindicated in pregnancy due to teratogenicity?

Accepted Answer

ACE inhibitors

Answer

ACE inhibitors are teratogenic, particularly in the second and third trimesters, causing fetal renal malformations, oligohydramnios, and skull hypoplasia.

Question 2

What is the first-line treatment for community-acquired pneumonia (CAP) in an otherwise healthy outpatient adult?

Accepted Answer

Azithromycin or doxycycline

Answer

IDSA/ATS guidelines recommend azithromycin or doxycycline monotherapy for healthy outpatients with CAP and no comorbidities or antibiotic use in the past 3 months.

Question 3

A patient on warfarin is started on rifampin. How does this affect warfarin dosing?

Accepted Answer

Warfarin dose must be increased due to CYP induction

Answer

Rifampin is a potent CYP450 inducer that significantly increases warfarin metabolism, reducing its anticoagulant effect and requiring a substantially higher warfarin dose.

Question 4

Which medication used for gout prevention requires monitoring for ocular toxicity, including retinal damage?

Accepted Answer

Hydroxychloroquine

Answer

Hydroxychloroquine (used for RA and lupus, sometimes related to inflammatory arthritis) can deposit in the retina, causing irreversible retinopathy with prolonged use.

Question 5

Which drug interaction can occur when combining an MAOI with meperidine (pethidine)?

Accepted Answer

Serotonin syndrome, potentially fatal

Answer

MAOIs inhibit monoamine oxidase, and meperidine blocks serotonin reuptake, causing dangerous serotonin accumulation that can lead to fatal serotonin syndrome.

AANP - American Association of Nurse Practitioners Practice Test

AANP - American Association of Nurse Practitioners Practice Test

AANP Pharmacology 3