UWorld UWorld System-Based Pathology

Question 1

In UWorld cardiology content, what ECG finding is most associated with Wolff-Parkinson-White (WPW) syndrome?

Accepted Answer

Short PR interval with a delta wave (slurred upstroke of the QRS)

Answer

Prolonged PR interval with dropped QRS complexes

Answer

ST elevation in all leads simultaneously

Answer

Peaked T waves with widened QRS

Question 2

Which pulmonary condition in UWorld is classically associated with the radiographic finding of 'honeycomb lung' on CT?

Accepted Answer

Idiopathic pulmonary fibrosis (IPF)

Answer

Pulmonary embolism

Answer

Lobar pneumonia

Answer

Sarcoidosis

Question 3

In UWorld nephrology, what is the classic urinalysis finding in acute tubular necrosis (ATN)?

Accepted Answer

Muddy brown granular casts

Answer

RBC casts

Answer

Waxy casts

Answer

WBC casts

Question 4

What UWorld hematology concept explains why sickle cell patients are functionally asplenic?

Accepted Answer

Repeated splenic infarctions from sickling cause autosplenectomy, leaving patients susceptible to encapsulated organisms

Answer

Sickle cell patients have surgically removed spleens at birth

Answer

The spleen is absent due to a developmental defect in sickle cell disease

Answer

Splenomegaly compresses splenic vasculature, reducing function

Question 5

In UWorld endocrinology, what distinguishes Cushing's disease from ectopic ACTH syndrome?

Accepted Answer

Cushing's disease is caused by a pituitary adenoma secreting ACTH, while ectopic ACTH is secreted by non-pituitary tumors like small cell lung cancer

Answer

Cushing's disease has lower cortisol levels than ectopic ACTH syndrome

Answer

Cushing's disease causes bilateral adrenal hyperplasia while ectopic ACTH does not

Answer

They are clinically identical and require genetic testing to distinguish

Question 6

What UWorld gastroenterology finding is characteristic of celiac disease on small bowel biopsy?

Accepted Answer

Villous atrophy with crypt hyperplasia and increased intraepithelial lymphocytes

Answer

Non-caseating granulomas throughout all layers of the bowel wall

Answer

Pseudomembranes overlying colonic mucosa

Answer

Cobblestoning with skip lesions in the terminal ileum