TBI TBI Pharmacological Management 3

Question 1

Which medication is prescribed for post-TBI headache that is refractory to standard analgesics?

Accepted Answer

Amitriptyline

Answer

Warfarin

Answer

Metformin

Answer

Ondansetron

Question 2

What is the main pharmacological goal when managing elevated ICP in a TBI patient?

Accepted Answer

Reduce ICP while maintaining adequate cerebral perfusion pressure

Answer

Increase cerebral perfusion pressure above 110 mmHg

Answer

Eliminate all CSF production

Answer

Induce pharmacological coma immediately

Question 3

Donepezil (an acetylcholinesterase inhibitor) is sometimes used post-TBI to address which deficit?

Accepted Answer

Memory and cognitive impairment

Answer

Motor weakness

Answer

Visual field loss

Answer

Autonomic instability

Question 4

Why must antidepressants be used cautiously during the early post-TBI period?

Accepted Answer

Many lower seizure threshold and can worsen cognitive function acutely

Answer

They increase ICP

Answer

They promote cerebral edema

Answer

They interfere with CT contrast

Question 5

Zolpidem has been reported to paradoxically improve arousal in some minimally conscious TBI patients due to what mechanism?

Accepted Answer

It paradoxically inhibits overactive inhibitory pathways, releasing functional circuits

Answer

It increases dopamine in the striatum

Answer

It reduces cerebral edema

Answer

It increases REM sleep duration

Question 6

Prophylactic antiepileptic therapy after TBI is typically continued for how long according to current guidelines?

Accepted Answer

7 days for early seizure prevention only

Answer

6 months

Answer

1 year

Answer

Lifelong therapy