STP Research, Development & Innovation 3

Question 1

Which element of a protocol is specifically designed to describe how missing data will be handled in the statistical analysis?

Accepted Answer

Statistical analysis plan (SAP)

Answer

The Statistical Analysis Plan pre-specifies analytical methods including imputation strategies for missing data before unblinding.

Question 2

A healthcare scientist identifies a potential improvement to an existing NHS diagnostic pathway. Under the NHS NICE Evidence Standards Framework, what category would this innovation most likely fall into?

Accepted Answer

Diagnostics guidance

Answer

NICE Diagnostics Guidance evaluates new or existing diagnostic technologies, including tests and decision-support tools used in NHS practice.

Question 3

What is the key distinction between a systematic review and a narrative review?

Accepted Answer

Systematic reviews use a pre-registered, reproducible search and selection strategy; narrative reviews do not

Answer

Systematic reviews follow a rigorous, pre-specified, and reproducible methodology to minimise bias in identifying and synthesising evidence.

Question 4

In the innovation adoption lifecycle, which group is characterised by adopting new technologies only after the majority of the market has done so?

Accepted Answer

Laggards

Answer

Late majority adopters are sceptical and adopt innovations only after most others have, often driven by economic necessity or peer pressure.

Question 5

Which document outlines the conditions under which a sponsor delegates specific trial responsibilities to the investigator site?

Accepted Answer

Clinical Trial Agreement (CTA) / delegation log

Answer

A delegation log (often part of the Clinical Trial Agreement) formally records which responsibilities the sponsor has delegated to site personnel.

(STP) Scientist Training Programme Practice Test

(STP) Scientist Training Programme Practice Test

STP Research, Development & Innovation 3