SMLE Pharmacology

Question 1

A patient with heart failure is prescribed digoxin. Which electrolyte abnormality increases the risk of digoxin toxicity?

Accepted Answer

Hypokalaemia

Answer

Hyperkalaemia

Answer

Hypernatraemia

Answer

Hypercalcaemia

Question 2

Which antibiotic class is associated with tendon rupture, particularly the Achilles tendon, especially in elderly patients?

Accepted Answer

Fluoroquinolones

Answer

Penicillins

Answer

Cephalosporins

Answer

Macrolides

Question 3

A patient on warfarin therapy has an INR of 8.5 with no active bleeding. What is the most appropriate management?

Accepted Answer

Hold warfarin and administer oral vitamin K

Answer

Continue warfarin at the same dose

Answer

Give fresh frozen plasma immediately

Answer

Administer prothrombin complex concentrate

Question 4

Which drug is the antidote for opioid overdose?

Accepted Answer

Naloxone

Answer

Flumazenil

Answer

N-acetylcysteine

Answer

Atropine

Question 5

A pregnant woman requires treatment for a urinary tract infection. Which antibiotic is considered safest in the first trimester?

Accepted Answer

Amoxicillin

Answer

Ciprofloxacin

Answer

Tetracycline

Answer

Trimethoprim

Question 6

A patient on metformin is scheduled for a CT scan with IV contrast. What precaution should be taken?

Accepted Answer

Hold metformin for 48 hours after the contrast study

Answer

No precaution needed

Answer

Switch to insulin permanently

Answer

Administer metformin with the contrast