SMLE Pharmacology 2

Question 1

Which medication is contraindicated in patients with a history of acute intermittent porphyria?

Accepted Answer

Barbiturates

Answer

Paracetamol

Answer

Aspirin

Answer

Metformin

Question 2

A patient with asthma is prescribed a non-selective beta-blocker for hypertension. What is the expected adverse effect?

Accepted Answer

Bronchospasm

Answer

Hyperglycaemia

Answer

Tachycardia

Answer

Polyuria

Question 3

A patient on isoniazid for tuberculosis develops peripheral neuropathy. Which vitamin deficiency is responsible and what supplement prevents this?

Accepted Answer

Vitamin B6 (pyridoxine)

Answer

Vitamin B12 (cyanocobalamin)

Answer

Vitamin B1 (thiamine)

Answer

Vitamin C (ascorbic acid)

Question 4

Which class of antihypertensive drugs is teratogenic and absolutely contraindicated in pregnancy?

Accepted Answer

ACE inhibitors and ARBs

Answer

Calcium channel blockers

Answer

Methyldopa

Answer

Labetalol

Question 5

A patient on rifampicin for tuberculosis is also taking warfarin. What effect does rifampicin have on warfarin levels?

Accepted Answer

Decreases warfarin levels (inducer)

Answer

Increases warfarin levels (inhibitor)

Answer

No interaction

Answer

Unpredictable effect

Question 6

Which antidiabetic medication works by inhibiting sodium-glucose cotransporter 2 (SGLT2) in the proximal tubule?

Accepted Answer

Empagliflozin

Answer

Metformin

Answer

Glipizide

Answer

Sitagliptin