Hospital Pharmacy Operations Flashcards

A hospital pharmacy is implementing an antibiotic stewardship program (ASP). Which pharmacist-led intervention has the strongest evidence for reducing antibiotic overuse?

Answer: Prospective audit and feedback — pharmacist reviews antibiotic prescriptions and provides real-time recommendations to prescribers

Prospective audit and feedback (PAF) is the most effective and widely adopted ASP strategy. A clinical pharmacist (ideally with ID support) reviews antibiotic prescriptions daily and provides face-to-face or written recommendations for de-escalation, dose optimization, IV-to-oral switch, or discontinuation. Pre-authorization is also effective but more restrictive.

A pharmacist is counseling a patient at discharge on a new oral anticoagulant (DOAC). Which point is most critical for apixaban?

Answer: Do not stop apixaban without consulting your physician — stopping suddenly for procedures or missed doses requires specific bridging guidance

DOACs have no routine monitoring requirement, but patients must understand: never stop abruptly (thrombosis risk), what to do for missed doses (take soon if 6 hours for twice-daily), managing for procedures, signs of bleeding, and drug interactions. Stopping DOACs without guidance causes rebound thrombosis risk in AF patients.

A pharmacy technician makes an error that results in a patient receiving 10 times the correct dose of a medication. What is the pharmacist supervisor's immediate responsibility?

Answer: Ensure immediate patient safety (notify clinical team), complete incident report, investigate root cause, and implement preventive measures

A 10-fold overdose error requires immediate patient safety intervention as first priority — notify the clinical team immediately. Incident reporting, root cause analysis (system failure, not just human error), and prevention through system improvements are all required. Blaming and punishing individuals without system review perpetuates errors.

A hospital pharmacist is reviewing the formulary and notes that two different formulations of morphine (immediate-release and extended-release) look identical in packaging. What action should be taken?

Answer: Apply auxiliary labels, store in different locations, use tall man lettering, and alert nursing staff — classic LASA hazard

Morphine IR vs. ER is a high-risk LASA (look-alike) medication pair. Interventions: separate storage locations, different-colored auxiliary labels, LASA stickers on both products, tall man lettering on labels, prescriber and nursing education. Ten-fold dosing errors can occur if ER is given as IR frequency or vice versa.

A pharmacist is preparing IV admixtures and calculates that a preparation's pH falls outside the acceptable range. What is the potential clinical consequence of infusing an IV solution with extremely low pH (pH 2)?

Answer: Severe phlebitis, vein damage, and pain — also potential systemic acidosis if given in large volume

Blood pH is tightly regulated at 7.35–7.45. IV solutions with pH 9 can cause: phlebitis (vein wall irritation/inflammation), thrombophlebitis, patient pain, and vein damage. Highly acidic or basic solutions should be administered via central venous access. Large volumes of highly acidic solutions can cause metabolic acidosis.

A hospital pharmacy is developing a policy for look-alike sound-alike (LASA) medications. Which strategy is recommended by ISMP (Institute for Safe Medication Practices)?

Answer: Segregated storage, auxiliary labels, different colored caps, tall man lettering, staff education, and removal from automatic dispensing cabinets where possible

ISMP recommends a multi-faceted LASA strategy: segregated storage (physical separation), tall man lettering, distinctive labeling/auxiliary labels, different colored caps or labels where possible, staff education and alerts, and minimizing LASA pairs in ADC override lists. No single intervention is sufficient alone.