Saudi Prometric Pharmacist Dispensing and Compounding 2

Question 1

What is aseptic technique in sterile compounding?

Accepted Answer

A set of procedures to prevent microbial contamination during preparation of sterile products, including laminar flow hoods and sterile gowning

Answer

Aseptic technique includes: working in a certified laminar airflow hood (ISO 5), proper garbing (sterile gown, gloves, mask, hair cover), surface disinfection with 70% isopropyl alcohol, first-air principles, sterile supply handling, and environmental monitoring.

Question 2

What is the beyond-use date (BUD) for a compounded preparation?

Accepted Answer

The date after which a compounded preparation should not be used, determined by stability data and USP guidelines

Answer

BUD is assigned based on USP guidelines considering: formulation type, container, storage conditions, and available stability data. For non-sterile preparations: generally not more than 180 days or the shortest remaining expiry of ingredients. For sterile preparations: based on USP <797> risk levels.

Question 3

What are the requirements for handling hazardous drugs during compounding?

Accepted Answer

Use a biological safety cabinet, double gloving, protective gown, closed-system transfer devices, and proper waste disposal

Answer

Hazardous drug handling (USP <800>, adapted in Saudi hospitals) requires: Class II biological safety cabinet, double chemotherapy gloves, non-permeable gown, eye protection, closed-system transfer devices, designated negative-pressure room, proper waste disposal, and staff health monitoring.

Question 4

What calculations are commonly required in pharmacy compounding?

Accepted Answer

Dilution calculations, concentration conversions, alligation, isotonicity adjustments, and dose-weight calculations

Answer

Compounding calculations include: dilution (C1V1=C2V2), concentration conversions (mg/mL, %, w/w), alligation (mixing different concentrations), isotonicity adjustment (NaCl equivalents), pediatric dose calculations (mg/kg), and proportion/ratio calculations.

Question 5

What quality control measures should be performed on compounded preparations?

Accepted Answer

Visual inspection, weight/volume verification, pH testing when applicable, sterility testing for high-risk preparations, and documentation of all results

Answer

Quality control includes: visual inspection (clarity, color, particulates), weight/volume verification (within acceptable range), pH testing (for solutions), potency testing (when feasible), sterility and endotoxin testing (for sterile preparations), and complete documentation of all QC results.

Saudi Prometric Pharmacist Practice Test

Saudi Prometric Pharmacist Practice Test

Saudi Prometric Pharmacist Dispensing and Compounding 2