Pharmacy Therapeutics 2

Question 1

A patient with atrial fibrillation and CrCl of 35 mL/min is started on a DOAC. Which agent requires the most significant dose reduction at this renal function level?

Accepted Answer

Dabigatran

Answer

Dabigatran is primarily renally eliminated and is contraindicated or requires substantial dose reduction at CrCl <30 mL/min, with caution at 30–50 mL/min.

Question 2

Which of the following is the preferred first-line pharmacological treatment for generalized anxiety disorder (GAD) in adults?

Accepted Answer

Sertraline

Answer

SSRIs such as sertraline are first-line for GAD because of their favorable safety profile and efficacy with long-term use.

Question 3

A patient on warfarin has an INR of 9 with no active bleeding. What is the most appropriate management?

Accepted Answer

Hold warfarin and give oral vitamin K 2.5 mg

Answer

For supratherapeutic INR (>8) without bleeding, holding warfarin and giving low-dose oral vitamin K (2–2.5 mg) is recommended to lower INR without over-correction.

Question 4

Which antiepileptic drug is considered safest for use during pregnancy in women with epilepsy?

Accepted Answer

Lamotrigine

Answer

Lamotrigine has the most favorable fetal safety profile among antiepileptics and is preferred when epilepsy must be treated during pregnancy.

Question 5

In a patient with Stage 3 chronic kidney disease and type 2 diabetes, which glucose-lowering agent offers the most evidence for renal protection?

Accepted Answer

Empagliflozin

Answer

SGLT2 inhibitors like empagliflozin reduce intraglomerular pressure and have demonstrated cardiorenal protective effects in CKD with diabetes.

Pharmacy Practice Test

Pharmacy Practice Test

Pharmacy Therapeutics 2