Pharmacy Pharmacokinetics 2

Question 1

Which plasma protein is the primary binding protein for most acidic drugs?

Accepted Answer

Albumin

Answer

Albumin is the predominant plasma protein for binding acidic drugs (e.g., warfarin, NSAIDs), while alpha-1-acid glycoprotein primarily binds basic drugs.

Question 2

A patient with severe hypoalbuminemia is receiving a drug that is 95% protein-bound. What effect would you expect?

Accepted Answer

Increased free drug concentration and potential toxicity

Answer

With less albumin available for binding, more drug remains unbound (free), increasing the pharmacologically active fraction and the risk of toxicity.

Question 3

Which of the following best describes zero-order pharmacokinetics?

Accepted Answer

Drug concentration decreases by a fixed amount per unit time and half-life increases with dose

Answer

Zero-order kinetics occur when elimination capacity is saturated; a constant amount (not percentage) of drug is eliminated per unit time, so half-life is not constant and increases with higher doses.

Question 4

Creatinine clearance (CrCl) is most commonly used clinically to estimate:

Accepted Answer

Renal function for drug dosing adjustments

Answer

CrCl is the standard marker for glomerular filtration rate (GFR) and is used to estimate renal function to guide dose adjustments for renally eliminated drugs.

Question 5

The Cockcroft-Gault equation is used in pharmacy practice to estimate:

Accepted Answer

Creatinine clearance (CrCl) as a surrogate for GFR

Answer

The Cockcroft-Gault equation estimates CrCl using serum creatinine, age, weight, and sex, and is the standard method for renal dose adjustment calculations.

Pharmacy Practice Test

Pharmacy Practice Test

Pharmacy Pharmacokinetics 2