Pharmacy Compounding 4

Question 1

A compounder needs to prepare 200 mL of a 2% w/v solution from a 10% w/v stock solution. How many mL of stock solution are needed?

Accepted Answer

40 mL

Answer

Using C1V1 = C2V2: (10%)(V1) = (2%)(200 mL), so V1 = 40 mL.

Question 2

According to USP <797>, Category 1 CSPs (compounded sterile preparations) with no antimicrobial preservative stored at room temperature have a BUD of:

Accepted Answer

24 hours

Answer

USP <797> (2023) assigns a 24-hour BUD at controlled room temperature for Category 1 CSPs without antimicrobial preservatives.

Question 3

Which type of water is required for preparing compounded sterile preparations (CSPs)?

Accepted Answer

Sterile Water for Injection (WFI)

Answer

Sterile Water for Injection (WFI) meets USP standards for sterility, pyrogen limits, and ionic purity required for CSPs.

Question 4

When compounding a capsule, what excipient is commonly added as a glidant to improve powder flow?

Accepted Answer

Colloidal silicon dioxide (Cab-O-Sil)

Answer

Colloidal silicon dioxide functions as a glidant by reducing interparticulate friction and improving powder flow in capsule filling.

Question 5

A pharmacy must conduct media-fill testing when performing sterile compounding. The primary purpose is to:

Accepted Answer

Verify the aseptic technique of the compounder

Answer

Media-fill testing uses a growth medium in place of the drug to simulate the compounding process and verify that the compounder's aseptic technique does not introduce contamination.

Pharmacy Practice Test

Pharmacy Practice Test

Pharmacy Compounding 4