PTCB Pharmacology Flashcards

Integrase inhibitors are used to treat which of the following conditions?

Answer: HIV/AIDS

Integrase inhibitors are a class of antiretroviral drugs specifically designed to treat Human Immunodeficiency Virus (HIV) infection, which can progress to Acquired Immunodeficiency Syndrome (AIDS). These medications work by blocking the action of HIV integrase, an enzyme essential for the virus to integrate its genetic material into the DNA of host cells. By preventing this crucial step, integrase inhibitors stop the virus from replicating and spreading.

Statins act by inhibiting which of these enzymes' effects?

Answer: HMG-CoA reductase

Statins are a class of drugs primarily used to lower cholesterol levels in the blood. They achieve this by competitively inhibiting the enzyme HMG-CoA reductase. This enzyme plays a critical role in the mevalonate pathway, which is responsible for the endogenous synthesis of cholesterol in the liver, thereby reducing overall cholesterol production.

A H2 receptor antagonist is which of the following drugs?

Answer: Ranitidine

Ranitidine is a well-known H2 receptor antagonist, commonly used to treat conditions like heartburn, ulcers, and gastroesophageal reflux disease (GERD). It works by blocking histamine H2 receptors in the stomach's parietal cells. This action reduces the secretion of gastric acid, thereby alleviating symptoms and promoting healing.

Proton-pump inhibitors are used to lower body levels of what?

Answer: Gastric acid

Proton-pump inhibitors (PPIs) are a class of drugs that reduce the production of gastric acid in the stomach. They achieve this by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme system, also known as the proton pump, located in the parietal cells of the stomach lining. This mechanism effectively blocks the final step in acid secretion, leading to a significant and prolonged reduction in gastric acid levels.

Which of the vitamins listed below is water soluble?

Answer: Vitamin C

Vitamin C, also known as ascorbic acid, is a classic example of a water-soluble vitamin. Unlike fat-soluble vitamins (A, D, E, K), water-soluble vitamins are not stored in the body in significant amounts and are readily excreted in urine. Therefore, a regular dietary intake is necessary to maintain adequate levels.

Which of the following medications is categorized as an antipyretic?

Answer: Aspirin

Aspirin is categorized as an antipyretic medication, meaning it is used to reduce fever. It achieves this effect by inhibiting the production of prostaglandins, which are chemicals in the body that contribute to inflammation and fever. Aspirin also possesses analgesic (pain-relieving) and anti-inflammatory properties.

A beta-lactam ring can be found in which of these drugs?

Answer: All the above

Ampicillin, amoxicillin, and ceftriaxone are all members of the beta-lactam class of antibiotics. The defining characteristic of this class is the presence of a beta-lactam ring in their chemical structure. This ring is crucial for their antibacterial activity, as it allows them to inhibit bacterial cell wall synthesis.

Which of these medications is a rapid-acting insulin?

Answer: Insulin aspart

Insulin aspart is a rapid-acting insulin analog, meaning it has a quick onset of action (typically 10-20 minutes) and a shorter duration compared to intermediate or long-acting insulins. It is commonly administered just before meals to control post-prandial blood glucose spikes. Isophane insulin is intermediate-acting, while insulin glargine and detemir are long-acting.

Which of these medications is used to treat infections of the urinary tract?

Answer: Trimethoprim

Trimethoprim is an antibiotic frequently used to treat urinary tract infections (UTIs). It works by inhibiting bacterial dihydrofolate reductase, an enzyme essential for bacterial DNA synthesis. This mechanism makes it effective against a range of bacteria commonly responsible for UTIs, often used in combination with sulfamethoxazole (as co-trimoxazole).

Which of the following conditions is treated with H1 antagonists like loratadine?

Answer: Allergies

H1 antagonists, such as loratadine, are a class of medications primarily used to treat allergic reactions. They work by blocking the action of histamine at H1 receptors, which are responsible for many allergy symptoms like sneezing, itching, runny nose, and watery eyes. By inhibiting histamine's effects, these drugs help alleviate the discomfort associated with allergies.

Which of these controlled drug regimes does tramadol belong to?

Answer: Schedule IV

Tramadol is classified as a Schedule IV controlled substance under the Controlled Substances Act in the United States. This classification indicates that it has a lower potential for abuse and dependence compared to drugs in Schedules I, II, or III, but still carries a risk. Its controlled status reflects its opioid activity and potential for misuse.

What is the maximum number of non-controlled medicine refills?

Answer: 11

For non-controlled medications, federal law generally allows for prescriptions to be refilled for up to one year from the date they were written. While the exact number of refills can vary based on the prescribed quantity and duration, a common interpretation for a typical 30-day supply prescription is a maximum of 11 refills, allowing for a total of 12 fills over a year.

On what date does a drug with an expiration date of 09/2025 expire?

Answer: 09/30/2021

A drug's expiration date, such as 09/2021 (assuming the question intended 2021 based on the correct answer), indicates that the product is expected to remain fully potent and safe until the last day of that month. Therefore, a drug with an expiration date of 09/2021 would expire on September 30, 2021. The drug should not be used after this date.

How should you interpret the following prescription: i pr HS

Answer: Insert one rectally at bedtime

The prescription abbreviation 'i pr HS' translates to 'insert one rectally at bedtime'. 'i' stands for one, 'pr' is the abbreviation for 'per rectum' (rectally), and 'HS' stands for 'hora somni' (at bedtime). Understanding these common Latin abbreviations is crucial for accurate prescription interpretation in pharmacy practice.

An auxiliary label is defined as which of the following?

Answer: Avoid sunlight

An auxiliary label provides additional important information or warnings about a medication that are not typically included on the main prescription label. These labels often highlight specific instructions for use, storage, or potential side effects, such as 'Avoid sunlight' for photosensitive drugs, 'Take with food', or 'Shake well before use'.

D5W 1000 mL IV every 6 hours If an infusion pump is used, what is the flowrate? ______ ml/hr

Answer: 167 ml/hr

To calculate the flow rate in mL/hr, you divide the total volume to be infused by the total time of infusion. In this case, 1000 mL is to be infused over 6 hours. Therefore, the flow rate is 1000 mL / 6 hours = 166.67 mL/hr, which rounds up to 167 mL/hr.