Pharmacology Autonomic Nervous System Pharmacology Questions and Answers 1

Question 1

A 68-year-old male with benign prostatic hyperplasia (BPH) and hypertension is prescribed a medication that provides relief for both conditions. Which of the following mechanisms of action is most likely responsible for the therapeutic effects of this drug?

Accepted Answer

Blockade of alpha-1 adrenergic receptors

Answer

Alpha-1 adrenergic antagonists, such as prazosin and doxazosin, block alpha-1 receptors on the smooth muscle of the bladder neck and prostate, which improves urine flow in BPH. They also block alpha-1 receptors on vascular smooth muscle, leading to vasodilation and a decrease in blood pressure, making them effective for hypertension. Beta-1 blockade primarily affects the heart, muscarinic stimulation would worsen urinary symptoms, and acetylcholinesterase inhibition is not a primary treatment for these conditions.

Question 2

A patient is being treated with a non-selective beta-blocker for hypertension. Which of the following is a potential adverse effect that requires careful monitoring, especially in a patient with a history of respiratory disease?

Accepted Answer

Bronchoconstriction

Answer

Non-selective beta-blockers, like propranolol, block both beta-1 and beta-2 adrenergic receptors. Blockade of beta-2 receptors in the lungs can lead to bronchoconstriction, which can be dangerous for patients with asthma or COPD. Tachycardia is unlikely as beta-blockers slow the heart rate. While they can mask symptoms of hypoglycemia, bronchoconstriction is a more direct and concerning respiratory effect. Urinary retention is more characteristic of anticholinergic drugs.

Question 3

An elderly patient is administered atropine as a preanesthetic agent to reduce secretions. Which of the following signs would most likely indicate atropine toxicity?

Accepted Answer

Dry mouth, blurred vision, tachycardia, and delirium

Answer

Atropine is a muscarinic antagonist. Toxicity, or an anticholinergic crisis, manifests as symptoms that are opposite to the parasympathetic 'rest-and-digest' functions. These include dry mouth (decreased salivation), blurred vision (mydriasis and cycloplegia), tachycardia (blockade of vagal tone), and central nervous system effects like confusion and delirium. The other options describe cholinergic crisis (A, B) or sympathetic overstimulation (C).

Question 4

A patient in septic shock is administered a continuous infusion of a drug that primarily acts as a potent alpha-1 adrenergic agonist to increase blood pressure. Which of the following drugs was most likely administered?

Accepted Answer

Phenylephrine

Answer

Phenylephrine is a selective alpha-1 adrenergic agonist that causes potent vasoconstriction of arterioles and veins, leading to an increase in systemic vascular resistance and blood pressure. This makes it useful in cases of vasodilatory shock. Isoproterenol and albuterol are primarily beta-agonists, and dobutamine is a beta-1 agonist, which would primarily increase heart rate and contractility without the potent vasoconstriction needed to reverse septic shock.

Question 5

Which of the following statements best describes the mechanism of action of pilocarpine when used to treat glaucoma?

Accepted Answer

It is a direct-acting muscarinic agonist that increases aqueous humor outflow.

Answer

Pilocarpine is a direct-acting cholinergic (muscarinic) agonist. In the eye, it stimulates muscarinic receptors on the ciliary muscle, causing it to contract. This contraction increases the outflow of aqueous humor through the trabecular meshwork, thereby reducing intraocular pressure in glaucoma.

Pharmacology Practice Test

Pharmacology Practice Test

Pharmacology Autonomic Nervous System Pharmacology Questions and Answers 1