Doctor of Pharmacy General Flashcards
7 cards from real Pharm.D. Doctor of Pharmacy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 7 Doctor of Pharmacy General flashcards as text
What is the therapeutic drug monitoring target trough for vancomycin AUC/MIC in serious MRSA infections?
Answer: 400–600 mg·h/L
Current ASHP/IDSA guidelines recommend a vancomycin AUC/MIC target of 400–600 mg·h/L for serious MRSA infections.
A pregnant patient in her first trimester needs an antibiotic. Which is generally considered safest?
Answer: Amoxicillin
Penicillins like amoxicillin are FDA Pregnancy Category B and considered safe throughout pregnancy.
What is the primary mechanism by which statins reduce cardiovascular risk?
Answer: Inhibiting HMG-CoA reductase to reduce cholesterol synthesis
Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, reducing LDL levels.
Which opioid is preferred for patients with renal failure due to lack of active metabolite accumulation?
Answer: Fentanyl
Fentanyl is metabolized to inactive metabolites and is preferred in renal failure to avoid accumulation of toxic active metabolites.
A pharmacist identifies a medication error before dispensing. What is the MOST appropriate first action?
Answer: Contact the prescriber to clarify and correct the order
Contacting the prescriber to clarify and correct the order is the appropriate first step in resolving a prescription error.
Which antiepileptic drug requires monitoring of serum sodium due to risk of hyponatremia?
Answer: Oxcarbazepine
Oxcarbazepine causes SIADH-like syndrome leading to hyponatremia, requiring periodic sodium monitoring.
What is the role of P-glycoprotein (P-gp) in drug disposition?
Answer: It is an efflux transporter that limits drug absorption and CNS penetration
P-gp is an ATP-dependent efflux pump that transports drugs out of cells, limiting intestinal absorption and CNS entry.