According to evidence-based practice principles, when a clinician encounters a PDD patient who has failed two adequate antidepressant trials, what should guide the next clinical decision?
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A
Systematic review of adequacy of prior trials, then consider augmentation, switching, or combination strategies per treatment algorithms
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B
Immediately refer to inpatient psychiatric hospitalization
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C
Discontinue all medication and rely solely on psychotherapy
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D
Diagnose treatment-resistant depression and stop active treatment attempts