Pharmacy Pharmacology 3

Question 1

What is the mechanism of action of ACE inhibitors in treating hypertension?

Accepted Answer

Inhibit the conversion of angiotensin I to angiotensin II

Answer

ACE inhibitors block angiotensin-converting enzyme, preventing formation of angiotensin II (a potent vasoconstrictor), reducing blood pressure.

Question 2

SSRIs are first-line treatment for depression because they selectively inhibit reuptake of which neurotransmitter?

Accepted Answer

Serotonin

Answer

SSRIs (Selective Serotonin Reuptake Inhibitors) block serotonin reuptake transporters, increasing serotonin availability in the synapse.

Question 3

Warfarin inhibits which vitamin to exert its anticoagulant effect?

Accepted Answer

Vitamin K

Answer

Warfarin inhibits vitamin K epoxide reductase, preventing recycling of vitamin K, which is essential for synthesis of clotting factors II, VII, IX, and X.

Question 4

Which opioid receptor is primarily responsible for analgesia and euphoria?

Accepted Answer

Mu (μ)

Answer

Mu (μ) opioid receptors mediate analgesia, euphoria, respiratory depression, and physical dependence — making them the primary target for opioid analgesics.

Question 5

A patient taking a monoamine oxidase inhibitor (MAOI) should avoid which food to prevent hypertensive crisis?

Accepted Answer

Aged cheeses

Answer

Aged cheeses contain tyramine. MAOIs block its breakdown, causing excessive norepinephrine release and severe hypertension (cheese reaction).

Pharmacy Practice Test

Pharmacy Practice Test

Pharmacy Pharmacology 3