MFDS Pharmacology 3

Question 1

Which corticosteroid preparation is most appropriate for topical treatment of oral mucosal lesions?

Accepted Answer

All are appropriate depending on severity

Answer

Hydrocortisone pellets suit localised lesions, betamethasone mouthwash is ideal for widespread lesions, and clobetasol is used for severe resistant cases, selected by lesion extent and severity.

Question 2

Carbamazepine is the drug of first choice for management of:

Accepted Answer

Trigeminal neuralgia

Answer

Carbamazepine, a sodium channel blocker, is the first-line treatment for trigeminal neuralgia due to its demonstrated efficacy in reducing the frequency and intensity of attacks.

Question 3

The mechanism of action of chlorhexidine as an antiseptic mouthwash is:

Accepted Answer

Disruption of bacterial cell membranes

Answer

Chlorhexidine is a cationic bisbiguanide that adsorbs onto negatively charged bacterial cell walls, disrupting membrane integrity and causing cytoplasmic precipitation.

Question 4

Erythromycin achieves its antibacterial effect by binding to the:

Accepted Answer

50S ribosomal subunit

Answer

Erythromycin (and other macrolides) bind to the 50S ribosomal subunit, blocking translocation and inhibiting bacterial protein synthesis.

Question 5

Which drug is used prophylactically to prevent infective endocarditis before high-risk dental procedures?

Accepted Answer

NICE guidelines no longer recommend routine antibiotic prophylaxis

Answer

NICE guideline CG64 (2008, maintained in reviews) concludes there is insufficient evidence that antibiotic prophylaxis prevents IE and recommends against routine prophylaxis for dental procedures.

MFDS Part 1 Practice Test

MFDS Part 1 Practice Test

MFDS Pharmacology 3