CCTC CCTC - Certified Clinical Transplant Coordinator Infection Prevention and Management Questions and Answers

Question 1

Which opportunistic infection is most commonly caused by reactivation of a latent fungal infection in immunocompromised transplant recipients in the US?

Accepted Answer

Pneumocystis jirovecii (PJP)

Answer

Pneumocystis jirovecii pneumonia (PJP) is the most common serious opportunistic fungal infection in transplant recipients, occurring due to latent organism reactivation under immunosuppression.

Question 2

A kidney transplant recipient on tacrolimus, mycophenolate, and prednisone presents 6 weeks post-transplant with fever, productive cough, and ground-glass opacities on chest CT. The most likely diagnosis is:

Accepted Answer

Cytomegalovirus (CMV) pneumonitis

Answer

CMV pneumonitis classically presents at 4–8 weeks post-transplant with fever, cough, and bilateral ground-glass opacities in a recipient on high-level immunosuppression.

Question 3

Standard post-transplant prophylaxis with trimethoprim-sulfamethoxazole (TMP-SMX) protects against which two pathogens simultaneously?

Accepted Answer

PJP and Toxoplasma gondii

Answer

TMP-SMX provides dual prophylaxis against Pneumocystis jirovecii pneumonia (PJP) and Toxoplasma gondii, and also provides some urinary tract infection prophylaxis.

Question 4

The donor-recipient CMV serostatus combination associated with the HIGHEST risk of CMV disease post-transplant is:

Accepted Answer

Donor positive / Recipient negative (D+/R−)

Answer

D+/R− mismatch carries the highest CMV disease risk because the seronegative recipient has no pre-existing immunity and receives a primary CMV infection from the donor organ.

Question 5

A transplant coordinator is counseling a new kidney transplant recipient about food safety. Which of the following foods should be AVOIDED post-transplant?

Accepted Answer

Unpasteurized soft cheeses and raw shellfish

Answer

Unpasteurized cheeses and raw shellfish carry Listeria, Salmonella, and Vibrio risks that are particularly dangerous in immunocompromised transplant recipients.

CCTC - Certified Clinical Transplant Coordinator Practice Test

CCTC - Certified Clinical Transplant Coordinator Practice Test

CCTC CCTC - Certified Clinical Transplant Coordinator Infection Prevention and Management Questions and Answers