ASCP Immunohematology (Blood Banking) 2

Question 1

Cryoprecipitate is the treatment of choice for which specific clotting factor deficiency?

Accepted Answer

Hemophilia A (Factor VIII deficiency)

Answer

Cryoprecipitate is enriched in Factor VIII, fibrinogen, von Willebrand factor, and Factor XIII, making it useful for hemophilia A and hypofibrinogenemia.

Question 2

Which blood group system is associated with the 'Bombay phenotype' (Oh) lacking the H antigen?

Accepted Answer

H system (FUT1 gene)

Answer

The Bombay phenotype results from homozygous FUT1 mutation, preventing H antigen synthesis; these individuals have anti-H and react with all ABO groups.

Question 3

Transfusion-related acute lung injury (TRALI) is primarily caused by:

Accepted Answer

Donor anti-HLA or anti-neutrophil antibodies reacting with recipient

Answer

TRALI occurs when donor antibodies (anti-HLA or anti-HNA) activate recipient neutrophils in the lungs within 6 hours of transfusion.

Question 4

Which RhIG (RhoGAM) dose is given at 28 weeks gestation for Rh prophylaxis?

Accepted Answer

300 µg (full dose)

Answer

The standard 300-µg dose of Rh immune globulin is given at 28 weeks and again within 72 hours postpartum to prevent Rh sensitization.

Question 5

Which test detects unexpected antibodies in a patient's serum before transfusion?

Accepted Answer

Antibody screen (indirect antiglobulin test)

Answer

The antibody screen tests patient serum against reagent RBCs with known antigens to detect clinically significant alloantibodies.

ASCP Practice Test

ASCP Practice Test

ASCP Immunohematology (Blood Banking) 2