ORE Part 1 Pharmacology 2

Question 1

Which drug should be available in every UK dental practice for the management of anaphylaxis?

Accepted Answer

Adrenaline (epinephrine)

Answer

Hydrocortisone

Answer

Chlorphenamine

Answer

Salbutamol

Question 2

What is the primary mechanism by which amoxicillin exerts its antibacterial effect?

Accepted Answer

Inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins

Answer

Inhibition of protein synthesis at the 30S ribosomal subunit

Answer

Inhibition of DNA gyrase

Answer

Disruption of the bacterial cell membrane

Question 3

A patient taking the direct oral anticoagulant (DOAC) apixaban attends for extraction. What is the current SDCEP advice?

Accepted Answer

Continue the DOAC and use local haemostatic measures

Answer

Stop the DOAC 48 hours before extraction

Answer

Switch to warfarin before extraction

Answer

Only extract under general anaesthetic in hospital

Question 4

Which drug is used as a reversal agent for benzodiazepine sedation in dentistry?

Accepted Answer

Flumazenil

Answer

Naloxone

Answer

Atropine

Answer

Neostigmine

Question 5

What is the recommended first-line analgesic regimen following dental extraction in an adult with no contraindications?

Accepted Answer

Ibuprofen 400mg and paracetamol 1g taken together

Answer

Codeine 60mg four times daily

Answer

Aspirin 600mg four times daily

Answer

Diclofenac 50mg three times daily alone

Question 6

Chlorhexidine gluconate mouthwash should not be used immediately after which toothpaste ingredient?

Accepted Answer

Sodium lauryl sulphate (SLS)

Answer

Fluoride

Answer

Calcium carbonate

Answer

Triclosan