OCN Oncology Pharmacology 2

Question 1

Which antifungal drug interaction is most important to monitor in patients receiving voriconazole and certain chemotherapy agents?

Accepted Answer

CYP450 enzyme inhibition increasing chemotherapy drug levels

Answer

Reduced antiemetic efficacy

Answer

Increased antibiotic resistance

Answer

Decreased steroid effectiveness

Question 2

Aromatase inhibitors (e.g., anastrozole, letrozole) are used in postmenopausal breast cancer patients to achieve which effect?

Accepted Answer

Block conversion of androgens to estrogen in peripheral tissues

Answer

Block estrogen at the receptor directly

Answer

Suppress ovarian estrogen production

Answer

Increase progesterone levels

Question 3

Tamoxifen requires conversion by CYP2D6 to its active metabolite endoxifen. What is the nursing implication?

Accepted Answer

Avoid CYP2D6 inhibitors (e.g., fluoxetine) that reduce tamoxifen efficacy

Answer

Encourage high-fat diet to improve absorption

Answer

Monitor for hypoglycemia regularly

Answer

Administer only with antacids

Question 4

Colony-stimulating factors (e.g., filgrastim/G-CSF) are used in oncology patients primarily for which purpose?

Accepted Answer

To stimulate neutrophil production and reduce febrile neutropenia risk

Answer

To prevent anemia from chemotherapy

Answer

To increase platelet counts

Answer

To reduce nausea from radiation

Question 5

Bisphosphonates such as zoledronic acid are used in oncology to treat which complications?

Accepted Answer

Bone metastases, hypercalcemia of malignancy, and osteoporosis prevention

Answer

Brain metastases

Answer

Liver metastases

Answer

Lymphedema

Question 6

Which corticosteroid is most commonly used as part of antiemetic regimens for highly emetogenic chemotherapy?

Accepted Answer

Dexamethasone

Answer

Prednisone

Answer

Hydrocortisone

Answer

Methylprednisolone