Practice Test Geeks(OCC) Oncology Chemotherapy Certification Practice Test
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Pharmacology of Chemotherapeutic Agents Flashcards

6 cards from real OCC practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 6 Pharmacology of Chemotherapeutic Agents flashcards as text

  1. Which class of chemotherapeutic agents is known to cause cardiotoxicity as a major side effect?

    Answer: Anthracyclines

    Anthracyclines, such as doxorubicin, are known for their effectiveness but also for their potential to cause dose-dependent cardiotoxicity.

  2. Which chemotherapeutic drug is associated with hemorrhagic cystitis?

    Answer: Cyclophosphamide

    Cyclophosphamide can cause hemorrhagic cystitis due to the toxic metabolite acrolein. Adequate hydration and mesna are used for prevention.

  3. What is the primary mechanism of action of antimetabolites in chemotherapy?

    Answer: Mimic nucleotides to inhibit DNA synthesis

    Antimetabolites interfere with DNA and RNA synthesis by mimicking normal substrates, ultimately inhibiting cell replication.

  4. Why is mesna co-administered with ifosfamide or cyclophosphamide?

    Answer: To protect the bladder from toxicity

    Mesna binds to and inactivates acrolein, a toxic byproduct that causes hemorrhagic cystitis, protecting the bladder lining.

  5. Which chemotherapeutic agent is commonly linked with nephrotoxicity requiring pre- and post-hydration protocols?

    Answer: Cisplatin

    Cisplatin is nephrotoxic and necessitates aggressive IV hydration to prevent renal damage.

  6. What is the primary dose-limiting toxicity of vincristine?

    Answer: Neurotoxicity

    Vincristine is associated with neurotoxicity, particularly peripheral neuropathy, which often limits its use.

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