A client presents with chronic low back pain and mentions they recently began a course of systemic corticosteroids for an autoimmune condition. Which physiological consideration most directly affects your choice of massage depth and pressure?
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A
Corticosteroids increase collagen cross-linking, making connective tissue more resistant to deformation
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B
Prolonged corticosteroid use suppresses fibroblast activity and reduces collagen synthesis, increasing tissue fragility
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C
Corticosteroids enhance mast cell degranulation, elevating the inflammatory response to mechanical stimuli
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D
Systemic corticosteroids cause peripheral vasoconstriction, reducing nutrient delivery to superficial fascia