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Asthma Medication Flashcards

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  1. Tezepelumab (Tezspire) is unique among approved asthma biologics because it targets which upstream cytokine, making it effective regardless of eosinophil count?

    Answer: TSLP (thymic stromal lymphopoietin)

    Tezepelumab targets TSLP, an epithelial-derived cytokine upstream of all type 2 inflammatory pathways, providing broad efficacy.

  2. A patient with aspirin-exacerbated respiratory disease (AERD) and asthma would MOST benefit from which add-on therapy?

    Answer: Leukotriene receptor antagonist (LTRA)

    AERD involves overproduction of cysteinyl leukotrienes, so LTRAs specifically blunt this pathway and improve both asthma and NSAID sensitivity.

  3. Which systemic corticosteroid course is recommended by NAEPP for an adult with a moderate-severe acute asthma exacerbation at hospital discharge?

    Answer: 3–5 day course of prednisone 40–60 mg/day

    NAEPP recommends a 3–5 day course of oral prednisone (40–60 mg/day) after acute exacerbation to prevent relapse.

  4. Cromolyn sodium prevents asthma by which mechanism?

    Answer: Stabilizing mast cell membranes to prevent degranulation

    Cromolyn sodium stabilizes mast cell membranes, preventing the release of inflammatory mediators upon allergen exposure.

  5. Which formoterol-containing combination ICS/LABA inhaler is FDA-approved for use as BOTH maintenance AND reliever therapy (MART/SMART strategy)?

    Answer: Budesonide/formoterol (Symbicort)

    Budesonide/formoterol (Symbicort) uses formoterol's rapid onset to allow single-inhaler maintenance and reliever therapy (SMART).

  6. A patient with severe persistent asthma and a serum total IgE of 380 IU/mL and confirmed allergic sensitization is a candidate for which biologic?

    Answer: Omalizumab (Xolair)

    Omalizumab binds free IgE and is indicated for moderate-to-severe allergic asthma with elevated IgE (30–700 IU/mL) and positive allergen skin tests.

  7. What is the primary reason magnesium sulfate IV is used in severe acute asthma exacerbations refractory to initial treatment?

    Answer: It causes bronchodilation by blocking calcium-mediated smooth muscle contraction

    Magnesium sulfate blocks calcium influx in bronchial smooth muscle, producing bronchodilation in severe refractory exacerbations.

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