Chemotherapy for Mesothelioma Flashcards
6 cards from real Mesothelioma Therapy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 Chemotherapy for Mesothelioma flashcards as text
What is the response rate of pemetrexed + cisplatin in mesothelioma clinical trials?
Answer: 41–45%
Clinical trials showed a response rate of approximately 41–45% for pemetrexed + cisplatin in mesothelioma, significantly higher than cisplatin alone.
Which systemic therapy replaced pemetrexed + cisplatin as preferred first-line treatment in some mesothelioma guidelines?
Answer: Nivolumab + ipilimumab (CheckMate 743)
Based on the CheckMate 743 trial, nivolumab + ipilimumab immunotherapy became the preferred first-line option over chemotherapy in many US guidelines.
What does 'maintenance chemotherapy' mean in the context of mesothelioma?
Answer: Continued low-dose chemotherapy after complete response to prevent recurrence
Maintenance chemotherapy refers to continued administration of a drug at lower doses after response to initial treatment to delay relapse.
Vinorelbine is occasionally used in mesothelioma as a(n):
Answer: Second- or third-line palliative treatment
Vinorelbine is used as a second- or third-line palliative treatment option for patients with relapsed or refractory mesothelioma.
Which route of administration is used for HIPEC chemotherapy?
Answer: Intraperitoneal (directly into the abdomen)
HIPEC delivers heated chemotherapy directly into the peritoneal (abdominal) cavity during surgery, maximizing local drug concentration.
Bevacizumab has been studied in mesothelioma as an addition to pemetrexed + cisplatin. What is its mechanism?
Answer: VEGF inhibition (anti-angiogenic)
Bevacizumab is an anti-VEGF monoclonal antibody that inhibits tumor angiogenesis, limiting blood supply to the tumor.