Chemotherapy for Mesothelioma Flashcards
6 cards from real Mesothelioma Therapy practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 Chemotherapy for Mesothelioma flashcards as text
What is the most common dose-limiting toxicity of pemetrexed in mesothelioma treatment?
Answer: Myelosuppression (neutropenia)
Myelosuppression, particularly neutropenia, is the most common dose-limiting toxicity of pemetrexed, requiring careful monitoring of blood counts.
Cisplatin-based chemotherapy requires adequate pretreatment hydration primarily to prevent which toxicity?
Answer: Nephrotoxicity (kidney damage)
Cisplatin is highly nephrotoxic, and aggressive IV hydration before and after administration is required to protect kidney function.
Which chemotherapy drug combination was approved for second-line mesothelioma in the US after initial chemotherapy failure?
Answer: Nivolumab + ipilimumab
Nivolumab combined with ipilimumab gained FDA approval for first-line mesothelioma treatment and is also used in subsequent lines after chemotherapy failure.
What is the purpose of corticosteroid premedication before pemetrexed infusion?
Answer: To prevent skin rash
Dexamethasone premedication is given before pemetrexed to prevent the skin rash that commonly occurs without prophylaxis.
In neoadjuvant chemotherapy for mesothelioma, when is chemotherapy administered relative to surgery?
Answer: Before surgery
Neoadjuvant chemotherapy is administered before surgery to shrink the tumor and assess chemosensitivity before planned surgical resection.
Which organ function must be closely monitored during cisplatin-based chemotherapy for mesothelioma?
Answer: Kidneys
Kidney function must be closely monitored during cisplatin therapy because cisplatin causes significant nephrotoxicity and requires dose adjustment for renal impairment.