Medical Technologist Test Immunology and Serology

Question 1

Which immunoglobulin class is the FIRST to be produced during a primary immune response?

Accepted Answer

IgM

Answer

IgM is the first antibody produced during a primary immune response before class switching to IgG and other isotypes occurs.

Question 2

The complement pathway activated directly by antigen-antibody complexes is the:

Accepted Answer

Classical pathway

Answer

The classical complement pathway is triggered when C1q binds to antigen-antibody (immune) complexes, initiating the cascade.

Question 3

Type I hypersensitivity (anaphylactic) reactions are primarily mediated by which immunoglobulin?

Accepted Answer

IgE

Answer

Type I hypersensitivity is mediated by IgE antibodies bound to mast cells and basophils, causing degranulation upon antigen re-exposure.

Question 4

A homogeneous ANA fluorescence pattern is most commonly associated with antibodies against:

Accepted Answer

Anti-dsDNA or anti-histone antibodies

Answer

A homogeneous ANA pattern reflects antibodies against double-stranded DNA or histone proteins and is classically associated with systemic lupus erythematosus.

Question 5

In the zone of equivalence during a precipitation reaction, which of the following occurs?

Accepted Answer

Optimal lattice formation produces maximum precipitate

Answer

In the zone of equivalence, antigen and antibody are present in optimal proportions, allowing maximum cross-linked lattice formation and precipitation.

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Medical Technologist Test Practice Test

Medical Technologist Test Immunology and Serology